KUSI San Diego people – transforming cancer treatment
October 25, 2015
New drug squashes cancer’s last-ditch efforts to survive
June 25, 2015
New gene discovered that stops the spread of deadly cancer
July 17, 2014
Cancer Breakthrough in San Diego
July 18, 2014
The Art and Science of Cuisine at the Salk Institute
January 23, 2014
Reuben Shaw, Isabel Cruz and Joy Houston.
Treating Cancer with Diabetes Drugs…and other Adventures in Basic Biomedical Research
November 7, 2012
A presentation to the SalkExcellerators
Salk science leads the way to discoveries that impact human lives: Diabetes
May 12, 2011
Reuben Shaw and Marc Montminy, of Salk’s Helmsley Center for Nutritional Genomics will be publishing back-to-back research papers in the May 13, 2011, issue of the prestigious journal Cell. These papers disclose critical discoveries in the area of diabetes. The Center was founded two years ago with a $ 5.5 million grant from the Leona M. and Harry B. Helmsley Charitable Trust.
Although the findings are separate research efforts, their collaboration and parallel endeavors made each of the discoveries successful. This work wouldn’t have been possible without the financial support of the trust, which funded crucial core equipment and enabled the members of the CNG to collaborate closely. (Reuben’s paper is co-authored by Ron Evans, also a member of the CNG and Marc, while Marc’s is co-authored by Reuben and John Thomas.)
Shaw/RE/MM paper: Uncovered new target that they proved can restore glucose levels to normal. “Fasting Pathway” points the way to new class of diabetes drugs — HDAC inhibitors may provide novel way to cut excessive blood glucose levels at the source.
Montminy/RS/JT paper: Discovered how insulin increases fat storage during feeding in fruit flies. The central circuitry of how animals regulate metabolism in response to fasting and feeding is conserved from fly all the way to man emphasizing the importance of class II HDAC’s in coordinating how different hormones direct the creation and use of glucose.
“Fasting pathway” points the way to new class of diabetes drugs
May 12, 2011
A uniquely collaborative study by researchers at the Salk Institute for Biological Studies uncovered a novel mechanism that turns up glucose production in the liver when blood sugar levels drop, pointing towards a new class of drugs for the treatment of metabolic disease.
Their findings, published in the May 13, 2011, issue of the journal Cell, revealed a crucial role for so called histone deacetylases (HDACs), a group of enzymes that is the target of the latest generation of cancer drugs. HDACs get sugar production rolling when blood glucose levels run low after prolonged periods of fasting or during the night. Read more>>
How cells running on empty trigger fuel recycling
December 23, 2010
In a paper published in the Dec. 23, 2010 edition of Science Express, a team led by Reuben Shaw, PhD., Howard Hughes Medical Institute Early Career Scientist and Hearst Endowment assistant professor in the Salk’s Molecular and Cell Biology Laboratory, reports that AMPK activates a cellular recycling process known as autophagy by activating an enzyme, known as ATG1, that jumpstarts the process. Read more>>