Reuben grew up in rural upstate New York, went to Cornell for undergraduate school where he did his thesis work with Rick Cerione. He then went to MIT for graduate school and did his PhD work in Tyler Jacks’ lab at the MIT Cancer Center where he focused on neurofibromatosis. Reuben did his postdoctoral work across the river at Harvard Medical School with Lew Cantley. The rest is in the screenplay.

Sonja grew up in a small town in upstate New York and moved just a couple hours east for her undergraduate work at the University of Rochester, where she obtained a B.S. in Biochemistry. She then moved to North Carolina to pursue her PhD in Pharmacology and Cancer Biology at Duke University under the mentorship of Robert Wechsler-Reya, where she used mouse models and in vivo therapeutics to understand pathways that drive tumor development and progression in pediatric brain tumors, focusing specifically on the subset of medulloblastomas driven by the classical Wnt and Shh pathways. During her tenure as a graduate student, the Wechsler-Reya lab relocated to the Sanford Consortium for Regenerative Medicine in sunny San Diego, where she completed her thesis work as a visiting scholar. Having embraced West Coast life, Sonja joined the Shaw lab in 2015 as a postdoctoral fellow where her work is now focused on understanding metabolic dependencies of tumors and developing novel targeted therapies against autophagy pathway regulators for therapeutic intervention in pancreatic and lung tumors.

Stephanie grew up in San Diego. She completed her B.Sc. in Cell, Molecular, and Developmental Biology at UC Riverside and went on to work at TriLink BioTechnologies in mRNA biology. Stephanie joined the Shaw lab in 2017 and is currently working towards her Ph.D. studying nuclear translocation events driven by changes in cellular energy status.

Lilly obtained her bachelor’s degree in Chemistry from Northwestern University in Illinois, after which she worked as a research associate at the Institute for Systems Biology back in her hometown, Seattle. She received her Ph.D. from McGill University in Montréal, Canada, where she studied the role of the PGC-1/Estrogen-Related Receptor pathway in the regulation of cancer metabolism in the lab of Dr. Vincent Giguère. She continues to study cancer metabolism, and its intersection with epigenetic modifiers, as a post-doc in the Shaw lab.

Eleanor grew up in the Gulf Coast area of the US. She obtained a B.A. in Molecular Biology from Pomona College in southern California, and then entered into the MIT Biology Department Ph.D. program. Her graduate work in the lab of Dr. Michael Hemann focused on utilizing functional genetic screens to investigate the response to targeted therapeutics in a mouse model of leukemia. She entered the Shaw lab as a postdoc in 2016, and studies the role of AMPK in epigenetic regulation and therapeutic response.

Hector received his B.S. in Biological Sciences from California State University, San Marcos. His research focused on characterization of essential genes crucial for the pathogenesis in Ambystoma tigrinum virus. During his time as an undergraduate, he became interested in researching the metabolic changes of cancer, and how they can potentially serve as therapeutic targets. In 2016 he entered the Biological Sciences Ph.D. program at UCSD, and subsequently joined the Shaw lab in early 2017. He studies the role of de novo lipogenesis in cancer.

Daniel grew up in a small town in central Mexico. He got his B.S. degree from UC San Diego and then completed his Ph.D. at UC San Francisco in Gerard Evan’s lab, where he worked on p53 restoration in tumors and also on establishing a novel mouse model for E2F regulation. He joined the Shaw lab as a postdoc in 2011. He studies the effects of LKB1-AMPK pathway reactivation in tumors.

Tina grew up in Karlskoga, Sweden. She obtained a M.Sc. in Chemical Biology from Linköping University, Sweden, and subsequently moved to Minneapolis to start graduate school at University of Minnesota. Her graduate work in the lab of Dr. David Bernlohr focused on inflammatory lipids in adipose biology. After completing her Ph.D. she joined the Shaw lab as a postdoc in 2013 to characterize downstream targets of AMPK signaling involved in liver metabolism.

Sébastien was born in Geneva, Switzerland. He obtained his M.Sc. and PhD from the University of Geneva. He performed his graduate work in the laboratory of Jean-Claude Martinou, where he focused on studying mitochondria and characterized the proteins essential for the mitochondrial pyruvate carrier. After completing his PhD, Sébastien joined the Shaw lab in 2014. His work is still focused on mitochondria and he studies the interplay between the AMPK signaling pathway and mitochondrial biology.

Pablo was born in Quito, Ecuador, and later moved to McLean, VA. He obtained an A.B. in Biochemical Sciences from Harvard College, followed by a research training fellowship at the NIH in the laboratory of Francis Collins on the genetic basis of Type 2 diabetes. Building on his interest on complex genetic diseases, he became passionate about studying the genetic and molecular basis of cancer. He obtained his Ph.D. in Genetics at Harvard Medical School, working with Karen Cichowski on the control and regulation of the Ras oncogene and the NF1 tumor suppressor in glioblastoma and neurofibromatosis. He joined the Shaw lab as a postdoctoral research fellow in 2013, where he currently develops and studies mouse models to understand the function of the LKB1 tumor suppressor and the AMPK-related kinase family in lung cancer. When not at the bench, Pablo serves as Chair of the Society of Research Fellows at Salk. He also loves to learn about the cultural traditions, stories, and (to eat!) cuisines from all around the world.

Chien-Min grew up in Taipei, Taiwan. He obtained M.S. degree in Biomedical Sciences from National Taiwan University and then completed his Ph.D. study in David Guertin’s Lab at University of Massachusetts Medical School (UMMS), where he worked on the role of mTOR complex 2 in tissue development and metabolism.  He joined the Shaw lab as a postdoc in late 2016 to study the function of ULK1-mediated autophagy in tumorigenesis.

Amanda grew up in rural New Hampshire. She then received her B.S. in Zoology from the University of New Hampshire. Soon after she moved to Boston and worked for the David Sabatini managing the mouse colony. In 2013, Amanda joined the Shaw Lab as a research technician, working mainly with mice.

Anwesh grew up in Bangalore, India where he obtained a Bachelor’s degree in Biotechnology from Visvesvaraya Technological University. He subsequently moved to California to pursue his MS in Biotechnology from the University of California, Irvine. Upon completion of his Master’s degree he worked at GNF in San Diego to develop Type-1 Diabetes therapies. He then joined UCSD to pursue his PhD studies and joined the Shaw Lab in 2015 to study the tumor suppressive role of LKB1 in cancer. He loves cricket, hiking and living in America’s Finest City.

Nazma grew up in Durham in the North East of England, where she initially studied Medicine (MBBS) for 3 years but later decided to complete her undergraduate as a BSc(Hons) in Biology. She subsequently did a Masters in Research (MRes) in Medical and Molecular Biosciences at the University of Newcastle, UK, followed by a PhD in Biochemistry in the laboratory of Prof Dario Alessi at the MRC PPU in Dundee, UK. Her PhD work was focused on understanding the regulation and function of the SGK3 kinase, a component of the PI3K signaling network. After completion of her PhD, she joined the Shaw lab as a postdoc in early 2018 to study AMPK signalling.

The Mouse Whisperer

Jeanine grew up in rural Nebraska and went to the University of Nebraska-Lincoln for undergraduate school where she did her thesis work with Julie Stone. She then went to Stanford for graduate school in Cancer Biology where she did her PhD work in Laura Attardi’s lab, where she studied the role of p53 and p53 target genes in Embryogenesis and Cancer. She joined the Shaw lab in the summer of 2014 and is interested in exploring the in vivo role of AMPK-regulation using mouse models.

Coming soon.