Trifecta Artist + Scientist Interview: Xuchi Naungayan Eggleton and Reuben Shaw

September 25, 2021 – January 16, 2022

Trifecta: Art, Science, Patron
Local artists and Salk Institute scientists collaborate in this interdisciplinary project that was inspired by the visionary gift of the Jacobs family. The Joan Klein and Irwin Mark Jacobs Senior Scientist Endowed Chair Challenge began in 2008 to encourage donors to establish endowed chairs in support of Salk scientists for their outstanding contributions to biological research.

Salk’s advancements in deadly lung cancers with Dr. Shaw—live on KUSI

August 12, 2019

KUSI – Salk Institute Develops Novel Cancer Treatment that Halts Fat Synthesis in Cells

September 20, 2016

New drug squashes cancer’s last-ditch efforts to survive

June 25, 2015

New gene discovered that stops the spread of deadly cancer

July 17, 2014

Salk Scientists Find Diabetes Drug Treats Lung Cancer

January 29, 2013

Read more»

The Art and Science of Cuisine at the Salk Institute

January 23, 2014

Reuben Shaw, Isabel Cruz and Joy Houston.

Salk science leads the way to discoveries that impact human lives: Diabetes

May 12, 2011

Reuben Shaw and Marc Montminy, of Salk’s Helmsley Center for Nutritional Genomics will be publishing back-to-back research papers in the May 13, 2011, issue of the prestigious journal Cell. These papers disclose critical discoveries in the area of diabetes. The Center was founded two years ago with a $ 5.5 million grant from the Leona M. and Harry B. Helmsley Charitable Trust.

Although the findings are separate research efforts, their collaboration and parallel endeavors made each of the discoveries successful. This work wouldn’t have been possible without the financial support of the trust, which funded crucial core equipment and enabled the members of the CNG to collaborate closely. (Reuben’s paper is co-authored by Ron Evans, also a member of the CNG and Marc, while Marc’s is co-authored by Reuben and John Thomas.)

Shaw/RE/MM paper: Uncovered new target that they proved can restore glucose levels to normal. “Fasting Pathway” points the way to new class of diabetes drugs — HDAC inhibitors may provide novel way to cut excessive blood glucose levels at the source.

Montminy/RS/JT paper: Discovered how insulin increases fat storage during feeding in fruit flies. The central circuitry of how animals regulate metabolism in response to fasting and feeding is conserved from fly all the way to man emphasizing the importance of class II HDAC’s in coordinating how different hormones direct the creation and use of glucose.

“Fasting pathway” points the way to new class of diabetes drugs

May 12, 2011

A uniquely collaborative study by researchers at the Salk Institute for Biological Studies uncovered a novel mechanism that turns up glucose production in the liver when blood sugar levels drop, pointing towards a new class of drugs for the treatment of metabolic disease.

Their findings, published in the May 13, 2011, issue of the journal Cell, revealed a crucial role for so called histone deacetylases (HDACs), a group of enzymes that is the target of the latest generation of cancer drugs. HDACs get sugar production rolling when blood glucose levels run low after prolonged periods of fasting or during the night. Read more>>

How cells running on empty trigger fuel recycling

December 23, 2010

In a paper published in the Dec. 23, 2010 edition of Science Express, a team led by Reuben Shaw, PhD., Howard Hughes Medical Institute Early Career Scientist and Hearst Endowment assistant professor in the Salk’s Molecular and Cell Biology Laboratory, reports that AMPK activates a cellular recycling process known as autophagy by activating an enzyme, known as ATG1, that jumpstarts the process. Read more>>